05 April 2013
Long-term survival rate of kidney graft and associated prognostic factors: A retrospective cohort study, 1994–2011Mohammad SaatchiABCDEF, Jalal PoorolajalABCDEFG, Mohammad Ali AmirzargarBDE, Hossein MahjubABD, Nader EsmailnasabDE
Ann Transplant 2013; 18:153-160
BACKGROUND: Despite several studies conducted to detect predisposing factors of graft rejection, results are inconsistent and limited. This study was performed to estimate long-term survival rate of kidney transplantation and to detect associated prognostic factors.
MATERIAL AND METHODS: This retrospective cohort study was conducted in Hamadan Province, in western Iran, enrolling 475 patients who had undergone kidney transplantation from 1994 to 2011. Data were extracted from patients’ medical records using a checklist. Chronic nonreversible graft rejection was considered as the event of interest. The duration of time between kidney transplantation and rejection was considered as the survival time. Life table, Kaplan-Meier curve, log-rank test and Cox proportional hazard model were used for data analysis.
RESULTS: Out of 475 transplantations, 55 episodes of rejection occurred. One-, 5-, 10-, 15-, and 18-year survival rates of transplantation were 97.1%, 92.3%, 86.2%, 77.6%, and 60.3%, respectively. The hazard ratio of graft rejection per 1-year increase in recipient age was 0.92 (P=0.001). The hazard ratio of graft rejection was 5.47 for grafts from deceased donors compared to grafts from living donors (P=0.025), and 3.54 (P=0.025) and 47.99 (P=0.001) in patients with episode of acute and hyperacute rejection compared to those without rejection episode, respectively.
CONCLUSIONS: Rejection of kidney transplantation is shaped by several prognostic factors, the most important of which are recipient age, type of donor (living vs. deceased), and episode of post-transplantation acute and hyperacute rejection.
Keywords: Kidney Transplantation, survival rate , cohort study, transplantation rejection, cumulative survival rate
29 March 2023 : EditorialEditorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...
Med Sci Monit In Press; DOI: 10.12659/MSM.940519
06 December 2022 : Original articleChanges in Physical Activity Due to Fear of COVID-19 and Its Impact on Depression Among Post-Liver Transpla...
Ann Transplant 2022; 27:e938239
04 October 2022 : Original articleIncidence of COVID-19 and Identification of Possible Risk Factors Associated with COVID-19 in Acute Renal T...
Ann Transplant 2022; 27:e937688
12 April 2022 : Letter/CorrespondencePancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas Transpla...
Ann Transplant 2022; 27:e935863
27 Mar 2023 : Original articleOutcomes of Kidney Transplantation in Older Recipients
Ann Transplant In Press; DOI: 10.12659/AOT.938692
27 Mar 2023 : Original articleThe Incidence of Brain-Dead Donors Based on Screening and Management Led by Intensivists
Ann Transplant In Press; DOI: 10.12659/AOT.939521
22 Mar 2023 : Original articleEffect of Sodium Bicarbonate Ringer’s Solution on Intraoperative Blood Gas Analysis and Postoperative Recov...
Ann Transplant In Press; DOI: 10.12659/AOT.939097
17 Mar 2023 : Original articleConverting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Followi...
Ann Transplant In Press; DOI: 10.12659/AOT.938731
Most Viewed Current Articles
24 Aug 2021 : Review articleNormothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives
Ann Transplant 2021; 26:e931664
26 Jan 2022 : Review articleRecurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models
Ann Transplant 2022; 27:e934924
29 Dec 2021 : Original articleEfficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...
Ann Transplant 2021; 26:e933588
15 Mar 2022 : Case reportCombined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...
Ann Transplant 2022; 27:e935860