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10 June 2013

Pathologic response to non-surgical locoregional therapies as potential selection criteria for liver transplantation for hepatocellular carcinoma

Massimiliano CantuAB, Tullio PiardiAE, Daniele SommacaleBF, Bernard ElleroCD, Marie Lorraine Woehl-JaegleDF, Maxime AudetB, Dimitri NtourakisDG, Philippe WolfAF, Patrick PessauxADE

DOI: 10.12659/AOT.883939

Ann Transplant 2013; 18:273-284

Abstract

BACKGROUND: Preoperative locoregional treatments (PLT) are performed to avoid progression before liver transplantation for hepatocellular carcinoma (HCC). The objective of this study was to analyze the prognostic factors affecting the outcome in patients who received PLT.

MATERIAL AND METHODS: A retrospective analysis of patients who underwent liver transplantation (LT) was performed. All patients who underwent PLT with confirmed pathological diagnosis of HCC were included. The rate of tumor necrosis (TN) was assessed by microscopic histological examination.

RESULTS: From January 1997 to December 2010, PLT was performed in 154 patients ROC analysis individuated a TN cut-off value at 40%. Ninety-one patients (59.1%) of the patients presented TN>40%. At multivariate analysis, TN<40% (HR=1.76; p=0.04) and vascular invasion (VI) (HR=2.16; p<0.01) were associated with lower Overall Survival (OS). At multivariate analysis, TN<40% (HR=1.59; p=0.001) and VI (HR=2.51; p=0.001) were significant associated with lower Disease Free Survival (DFS). One, 3 and 5 years OS was 87.9%, 82.0% and 69.1% for patients with TN>40% and 82.5%, 64.2% and 53.2% for those with TN<40% (p=0.02). Tumour size <5 cm (p=0.02); age <55 years (p=0.02); absence of VI (p=0.02) and multiple procedures (p=0.04) were predictive factors for TN>40%.

CONCLUSIONS: Response to preoperative locoregional treatment can be used as potential selection criteria for LT.

Keywords: chemoembolisation, radiofrequency ablation, Hepatocellular carcinoma (HCC), liver transplantation, locoregional traitment, cryoablation, Necrosis

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358