27 May 2014 : Case report
Utility of quantitative EBV DNA measurements in cerebrospinal fluid for diagnosis and monitoring of treatment of central nervous system EBV-associated post-transplant lymphoproliferative disorder after allogenic hematopoietic stem cell transplantationJoanna BocianBCDEF, Danuta Januszkiewicz-LewandowskaADE
Ann Transplant 2014; 19:253-256
BACKGROUND: Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after hematopoietic stem cell transplantation (HSCT) is a rare but life- threatening condition. Despite routine EBV DNA-emia monitoring in blood, central nervous system involvement of the disease is still associated with diagnostic difficulties and poor outcome.
CASE REPORT: We describe a 17-year-old female patient with severe aplastic anemia who developed central nervous system EBV-associated PTLD after matched unrelated allo- HSCT. EBV DNA concentration in cerebrospinal fluid was initially tested due to central nervous system-related symptoms. The sample was found to be highly EBV DNA-positive. Using quantitative real-time polymerase chain reaction (PCR) measurements, therapy efficiency was monitored until complete remission of the EBV-associated PTLD.
CONCLUSIONS: The case report illustrates the high utility of quantitative real-time PCR EBV measurements in cerebrospinal fluid for rapid diagnosis and therapy monitoring of central nervous system EBV-associated PTLDs after allo-HSCT.
Keywords: real- time PCR, Epstein- Barr virus, allogenic hematopoietic stem cell transplantation, Cerebrospinal Fluid, post- transplant lymphoproliferative disorder
06 December 2022 : Original articleChanges in Physical Activity Due to Fear of COVID-19 and Its Impact on Depression Among Post-Liver Transpla...
Ann Transplant 2022; 27:e938239
04 October 2022 : Original articleIncidence of COVID-19 and Identification of Possible Risk Factors Associated with COVID-19 in Acute Renal T...
Ann Transplant 2022; 27:e937688
12 April 2022 : Letter/CorrespondencePancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas Transpla...
Ann Transplant 2022; 27:e935863
12 November 2021 : Original articleCoronavirus Disease 2019 (COVID-19) in Solid Organ Transplant Recipients: A Case-Control Study
Ann Transplant 2021; 26:e933152
17 Mar 2023 : Original articleConverting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Followi...
Ann Transplant In Press; DOI: 10.12659/AOT.938731
17 Mar 2023 : Original articleLevels of Procollagen Type I C-Terminal Pro-Peptide and Galectin-3, Arterial Stiffness Measured By Pulse Wa...
Ann Transplant In Press; DOI: 10.12659/AOT.938137
08 Mar 2023 : Original articlePostoperative Outcomes in 415 Patients Following Liver Transplantation Using Extended Donor Criteria: A Stu...
Ann Transplant In Press; DOI: 10.12659/AOT.939060
08 Mar 2023 : Original articleEvaluation and Use of Organs from Donors Poisoned by Organophosphorus Pesticide
Ann Transplant In Press; DOI: 10.12659/AOT.939343
Most Viewed Current Articles
24 Aug 2021 : Review articleNormothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives
Ann Transplant 2021; 26:e931664
26 Jan 2022 : Review articleRecurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models
Ann Transplant 2022; 27:e934924
29 Dec 2021 : Original articleEfficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...
Ann Transplant 2021; 26:e933588
15 Mar 2022 : Case reportCombined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...
Ann Transplant 2022; 27:e935860