Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

11 September 2014 : Original article  

Evaluation of Renal Graft Function based on Standard Mathematical Formulas

Jerzy SieńkoABCDEFG, Agata JasiczekABDEF, Leszek PączekABDEF, Aleksandra Wyczałkowska-TomasikABDEF, Maciej KotowskiADEF, Adam NowackiADEF, Tadeusz SulikowskiADEF, Maciej RomanowskiADEF, Marek OstrowskiDF

DOI: 10.12659/AOT.890838

Ann Transplant 2014; 19:452-455

Abstract

BACKGROUND: Creatinine is a standard marker for estimation of the transplanted kidney function. Concentration values are used in mathematical equations for GFR (glomerular filtration rate) calculation, with MDRD (modification diet in renal disease) being most commonly used. Cystatin C is an alternative marker for changes in glomerular filtration, which is also used in eGFR (estimated GFR) formulas. The aim of this study was to reveal eGFR <60 ml/min/1.72 m^2 in a population of patients after renal transplant, with stable graft function, using different formulas.

MATERIAL AND METHODS: A group of 100 patients (56 females and 44 males) aged 20–78 years, took part in this study. Renal transplantation was conducted from 10 years to 10 months prior to the study. Estimated GFR was calculated with 4 formulas: MDRD, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), CKD-EPI cys (using cystatin C), and CKD-EPI mix (using creatinine and cystatin C). We used electronic calculators available on the National Kidney Foundation and the Nephron Information Center websites.

RESULTS: The occurrence of eGFR values <60 ml/min/1.73 m^2 was 28% according to MDRD formula, 23% according to CKD-EPI, 25% according to CDK-EPI cys, and 26%according to CDK-EPI mix.

CONCLUSIONS: Occurrence of GFR <60 ml/min/0.73 m^2 was the highest when calculated by MDRD formula, and the lowest when calculation was done with CDK-EPI. The significant discrepancy with different eGFR formula testing suggests the need for further research to find the best marker and/or formula for graft function estimation.

Keywords: cystatin C, Glomerular Filtration Rate, Kidney Transplantation

Add Comment 0 Comments

In Press

Original article  

Biopsychosocial Effects of Donor Traits on Heart Transplant Recipients

Ann Transplant In Press; DOI:  

Clinical Research  

Ten-Year Retrospective Analysis of Continuous Renal Replacement Therapy in Burn Patients: Impact on Surviva...

Ann Transplant In Press; DOI:  

Original article  

Factors Influencing Stress Disorders in Intensive Care Unit (ICU) Patients After Liver Transplantation: A C...

Ann Transplant In Press; DOI: 10.12659/AOT.944320  

Original article  

Hepatopulmonary Syndrome and Liver Transplantation: Impact on Survival and Postoperative Complications

Ann Transplant In Press; DOI: 10.12659/AOT.945297  

Most Viewed Current Articles

05 Apr 2022 : Original article   13,115

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

22 Nov 2022 : Original article   10,262

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

12 Jan 2022 : Original article   9,616

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

15 Mar 2022 : Case report   7,277

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358