Abstract

BACKGROUND: This is a single-center, retrospective study in the field of mobilization of hematopoietic stem cell from unrelated donors. We aimed to investigate whether delaying the last G-CSF dose after the start of apheresis influences its results.

MATERIAL AND METHODS: The medical records of 55 unrelated hematopoietic stem cell donors during the period 2010–2013 were analysed. In this series, 40 received donors the last G-CSF injection prior to the leukapheresis procedure, and 15 received the last injection after apheresis was initiated.

RESULTS: In the delayed G-CSF application group, more donors had already reached the requested cell number during first apheresis than in the group treated following the standard procedure (73% vs. 35%, respectively; p<0.01). Also, the average total G-CSF dose needed to mobilize the requested cell number was lower (41 µg/kg vs. 48 µg/kg, respectively, p=0.002).

CONCLUSIONS: Delayed G-CSF use in donors undergoing stem cell mobilization shows a better efficiency of stem cell mobilization.

Keywords: Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization, Peripheral Blood Stem Cell Transplantation