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27 November 2014 : Original article  

A New HC-A II Solution for Kidney Preservation: A Multi-Center Randomized Controlled Trial in China

Mingxing SuiBCDEF, Lei ZhangAB, Jinghui YangCDE, Li ZengBE, Wenyu ZhaoBD, Youhua ZhuA

DOI: 10.12659/AOT.892250

Ann Transplant 2014; 19:614-620


BACKGROUND: Hypertonic citrate adenine (HC-A) solution, containing citrate and adenine, has become the most widely used preservation solution in isolated kidney preservation in China. More than 30 years of clinical application has demonstrated that HC-A is safe and effective. With higher requirement for kidney preservation and less tolerance of preservation-related graft dysfunction, a new solution, HC-A II, for kidney preservation was developed by Shanghai Changzheng Hospital.

MATERIAL AND METHODS: Upon approval from the State Food and Drug Administration of China (SFDA), a multi-center randomized controlled trial was performed to study the efficacy and safety of HC-A II in kidney preservation from 2008 to 2012, using histidine-tryptophan-ketoglutarate solution (HTK) as control (HC-A, n=137, and HTK, n=140). There were no differences with regard to donor and recipient demographics or cold ischemia.

RESULTS: The trial results showed no significant difference in DGF rate, or patient or graft survival between the 2 groups. No significant difference between the 2 groups was found in the percentage of patients whose serum creatinine (SCr) test results returned to normal within 28 days (P>0.05), nor were there a significant difference in safety evaluation (P>0.05).

CONCLUSIONS: HC-A II and HTK appear to have similar efficacy in isolated kidney preservation.

Keywords: Kidney Transplantation, Organ Preservation, Organ Preservation Solutions, Randomized controlled trial

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358