Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

07 January 2015 : Original article  

Favorable Effects of Low-Dose Anti-Thymocyte Globulin in a Partially-Mismatched HLA Group in an Unrelated Allogeneic Stem Cell Transplantation Setting

Sang Kyun SohnABCDEF, Joon Ho MoonABCD

DOI: 10.12659/AOT.892298

Ann Transplant 2015; 20:7-15


BACKGROUND: The outcomes of unrelated stem cell transplantation (SCT) have improved with the use of anti-thymocyte globulin (ATG) to prevent graft-versus-host disease (GVHD) and graft rejection. Therefore, based on the HLA matching status classifications of well-matched (WM), partially-matched (PM), and mismatched (MM), the current study evaluated the role of ATG use among these 3 HLA groups in an unrelated SCT setting.

MATERIAL AND METHODS: Data from a total of 92 patients who received allogeneic SCT from unrelated donors (65 peripheral blood and 27 bone marrow) were retrospectively analyzed.

RESULTS: Among the 92 patients, 19 were classified as WM, 42 as PM, and 31 as MM. Fifty-seven patients (61.9%) received ATG as GVHD prophylaxis. The overall survival (OS) rate was higher for the WM group (83%) when compared to the PM group (54%) and MM group (34%, p=0.076). For the PM group, the OS was significantly improved with ATG (83.3% vs. 38.6%, p=0.018). However, there was no difference in OS with or without ATG for the MM group (32.4% vs. 41.7%, p=0.215). The use of ATG lowered the cumulative incidence of grade 3–4 acute GVHD (10% vs. 40.2%, p=0.068) and severe chronic GVHD (21.2% vs. 52.2%, p=0.037).

CONCLUSIONS: Use of ATG effectively improved the survival rate for the PM group in an unrelated SCT setting. However, this report has a major limitation in confirming the role of ATG for unrelated transplantation because the number of patients in each group was too small to compare therapy with ATG and without ATG, and a heterogeneous population was included in the current study. A larger study comparing different doses of ATG for unrelated PBSCT in a homogenous population will be needed to confirm the role of ATG.

Keywords: Anti-thymocyte Globuin, Stem Cell Transplantation, Unrelated Donors



06 December 2022 : Original article  

Changes in Physical Activity Due to Fear of COVID-19 and Its Impact on Depression Among Post-Liver Transpla...

Ann Transplant 2022; 27:e938239

12 April 2022 : Letter/Correspondence  

Pancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas Transpla...

Ann Transplant 2022; 27:e935863

12 November 2021 : Original article  

Coronavirus Disease 2019 (COVID-19) in Solid Organ Transplant Recipients: A Case-Control Study

Ann Transplant 2021; 26:e933152

In Press

17 Mar 2023 : Original article  

Converting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Followi...

Ann Transplant In Press; DOI: 10.12659/AOT.938731  

17 Mar 2023 : Original article  

Levels of Procollagen Type I C-Terminal Pro-Peptide and Galectin-3, Arterial Stiffness Measured By Pulse Wa...

Ann Transplant In Press; DOI: 10.12659/AOT.938137  

08 Mar 2023 : Original article  

Postoperative Outcomes in 415 Patients Following Liver Transplantation Using Extended Donor Criteria: A Stu...

Ann Transplant In Press; DOI: 10.12659/AOT.939060  

08 Mar 2023 : Original article  

Evaluation and Use of Organs from Donors Poisoned by Organophosphorus Pesticide

Ann Transplant In Press; DOI: 10.12659/AOT.939343  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358