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20 April 2015 : Original article  

Immunological Risk Factors in Biliary Strictures after Liver Transplantation

Federico MocchegianiA, Paolo VincenziE, Jacopo LanariB, Roberto MontaltiC, Daniele NicoliniB, Gianluca Svegliati BaroniD, Andrea RisalitiD, Marco VivarelliA

DOI: 10.12659/AOT.892393

Ann Transplant 2015; 20:218-224

Abstract

BACKGROUND: The purpose of this study was to investigate immunological risk factors associated with BS (Biliary Strictures) after LT (Liver Transplantation).

MATERIAL AND METHODS: The study included 192 patients out of 273 adult liver transplantations performed from August 2005 to December 2012, with a radiological or surgically proven biliary stricture. About 35 potential risk factors for biliary strictures were studied.

RESULTS: A biliary stricture was diagnosed in 22.9% of transplants; the anastomotic type and the non-anastomotic type complicated the transplantation in 18.2% and 7.8% of cases, respectively. Six patients (3.1%) presented both of forms. Univariate analysis using logistic regression showed that preoperative serum bilirubin level >2 mg/dl (P=0.040), donor age >46 years old (P=0.007), positive crossmatch (P=0.007), product of donor age and preoperative Model for End Stage Liver Disease (DMELD) >710 (P=0.011), occurrence of acute or chronic rejection (P=0.004; P=0.003), and biliary leak (P=0.002) were all significantly associated with the development of biliary stricture. At the multivariate analysis, Primary Biliary Cirrhosis (PBC) (P=0.019), donor age >46 years (P=0.008), crossmatch positivity (P=0.001), and acute or chronic rejection (P=0.005; P=0.043) appeared to be the only variables independently associated with the development of a biliary stricture.

CONCLUSIONS: Immunological risk factors (PBC, crossmatch positivity, acute and chronic rejection) emerged as being the most important variables associated to the development of biliary strictures after LT.

Keywords: Biliary Tract, Graft Rejection, Liver Transplantation, Postoperative Complications, Risk Factors

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358