Abstract

BACKGROUND: Currently, there is no universally accepted method to evaluate liver function post-orthotopic liver transplant (OLTx) and there are no early surrogate function markers to assess the impact of perioperative interventions in trial settings.

MATERIAL AND METHODS: In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.

RESULTS: In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.

CONCLUSIONS: PTLF score shows promise as an early surrogate marker of post-orthotopic liver transplantation mortality and morbidity by providing results within the first 7 days post-transplantation. PTLF score can potentially be used as a tool to assess the impact of perioperative interventions by predicting long-term outcomes early in the clinical course of transplant patients.

Keywords: Biological Markers, Graft Survival, Liver Function Tests, Liver Transplantation