09 April 2015 : Original article
Post-Transplant Liver Function Score as an Early Surrogate Marker of Long-Term Outcome
Mazen HassanainBCDE, Eve SimoneauBCE, Ahmad MadkhaliB, Nouf Al-SaatiF, Murad AljiffryBF, Jean TchervenkovE, Jeffrey BarkunEF, Peter MetrakosAEDOI: 10.12659/AOT.892414
Ann Transplant 2015; 20:198-205
Abstract
BACKGROUND: Currently, there is no universally accepted method to evaluate liver function post-orthotopic liver transplant (OLTx) and there are no early surrogate function markers to assess the impact of perioperative interventions in trial settings.
MATERIAL AND METHODS: In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.
RESULTS: In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.
CONCLUSIONS: PTLF score shows promise as an early surrogate marker of post-orthotopic liver transplantation mortality and morbidity by providing results within the first 7 days post-transplantation. PTLF score can potentially be used as a tool to assess the impact of perioperative interventions by predicting long-term outcomes early in the clinical course of transplant patients.
Keywords: Biological Markers, Graft Survival, Liver Function Tests, Liver Transplantation
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