23 April 2015 : Original article
Prognostic Factors of Lymphoma Patients after Autologous Stem Cell Transplantation
Fenghua QianCE, Wenxia FanBD, Xia WeiBD, Yan ZhuBD, Gang FuBD, Dabing QinBD, Xiaobo TianBD, Li PeiBD, Shuangnian XuBD, Jieping ChenAF, Yong ZhangAFDOI: 10.12659/AOT.892975
Ann Transplant 2015; 20:225-232
Abstract
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is considered to be a cure for lymphoma. However, factors related to its prognosis remain unclear.
MATERIAL AND METHODS: Eighty patients diagnosed with lymphoma and treated with autologous HSCT (Auto HSCT) were recruited. The primary endpoints included overall survival (OS) and progression-free survival (PFS).
RESULTS: After a median follow-up of 37.9 months, the 3-year OS was 75%. Univariate analysis showed age (P=0.020), elevated lactate dehydrogenase (LDH) (P=0.031), international prognostic index (IPI) (P=0.015), Eastern Cooperative Oncology Group (ECOG) (P=0.048), bone marrow involvement (P=0.038), and time to neutrophil recovery (P=0.043) were prognostic factors of lymphoma. Multivariate analysis revealed IPI (hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.09–2.34, P=0.016) and time to neutrophil recovery (HR 2.69, 95% CI 1.02–7.07, P=0.045) were independent factors correlated with OS.
CONCLUSIONS: IPI and neutrophil recovery are recommendatory predictors for lymphoma patients after Auto HSCT.
In Press
Original article
A New Routine Immunity Score (RIS2020) to Predict Severe Infection in Solid-Organ Transplant RecipientsAnn Transplant In Press; DOI: 10.12659/AOT.946233
Original article
Survival Analysis of Liver Transplants in Patients with Acute Liver Failure from Acetaminophen and Mushroom...Ann Transplant In Press; DOI: 10.12659/AOT.946485
Original article
Medication Adherence Among Pediatric Post-Heart Transplant Patients in a Tertiary Care HospitalAnn Transplant In Press; DOI: 10.12659/AOT.946905
Most Viewed Current Articles
03 Jan 2023 : Original article 6,377
Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...DOI :10.12659/AOT.938467
Ann Transplant 2023; 28:e938467
16 May 2023 : Original article 6,038
Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...DOI :10.12659/AOT.939258
Ann Transplant 2023; 28:e939258
15 Aug 2023 : Review article 5,925
Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ TransplantationDOI :10.12659/AOT.939750
Ann Transplant 2023; 28:e939750
17 Jan 2023 : Original article 5,156
Non-Cryopreserved Peripheral Blood Stem Cell Graft for Autologous Hematopoietic Stem Cell Transplantation i...DOI :10.12659/AOT.938595
Ann Transplant 2023; 28:e938595