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23 April 2015 : Original article  

Prognostic Factors of Lymphoma Patients after Autologous Stem Cell Transplantation

Fenghua QianCE, Wenxia FanBD, Xia WeiBD, Yan ZhuBD, Gang FuBD, Dabing QinBD, Xiaobo TianBD, Li PeiBD, Shuangnian XuBD, Jieping ChenAF, Yong ZhangAF

DOI: 10.12659/AOT.892975

Ann Transplant 2015; 20:225-232

Abstract

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is considered to be a cure for lymphoma. However, factors related to its prognosis remain unclear.

MATERIAL AND METHODS: Eighty patients diagnosed with lymphoma and treated with autologous HSCT (Auto HSCT) were recruited. The primary endpoints included overall survival (OS) and progression-free survival (PFS).

RESULTS: After a median follow-up of 37.9 months, the 3-year OS was 75%. Univariate analysis showed age (P=0.020), elevated lactate dehydrogenase (LDH) (P=0.031), international prognostic index (IPI) (P=0.015), Eastern Cooperative Oncology Group (ECOG) (P=0.048), bone marrow involvement (P=0.038), and time to neutrophil recovery (P=0.043) were prognostic factors of lymphoma. Multivariate analysis revealed IPI (hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.09–2.34, P=0.016) and time to neutrophil recovery (HR 2.69, 95% CI 1.02–7.07, P=0.045) were independent factors correlated with OS.

CONCLUSIONS: IPI and neutrophil recovery are recommendatory predictors for lymphoma patients after Auto HSCT.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358