Abstract

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is considered to be a cure for lymphoma. However, factors related to its prognosis remain unclear.

MATERIAL AND METHODS: Eighty patients diagnosed with lymphoma and treated with autologous HSCT (Auto HSCT) were recruited. The primary endpoints included overall survival (OS) and progression-free survival (PFS).

RESULTS: After a median follow-up of 37.9 months, the 3-year OS was 75%. Univariate analysis showed age (P=0.020), elevated lactate dehydrogenase (LDH) (P=0.031), international prognostic index (IPI) (P=0.015), Eastern Cooperative Oncology Group (ECOG) (P=0.048), bone marrow involvement (P=0.038), and time to neutrophil recovery (P=0.043) were prognostic factors of lymphoma. Multivariate analysis revealed IPI (hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.09–2.34, P=0.016) and time to neutrophil recovery (HR 2.69, 95% CI 1.02–7.07, P=0.045) were independent factors correlated with OS.

CONCLUSIONS: IPI and neutrophil recovery are recommendatory predictors for lymphoma patients after Auto HSCT.

Keywords: Lymphoma