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25 June 2015 : Original article  

Effects of Addition of Early Enteral Nutritional Support During the Postoperative Phase in Patients after Living-Donor Liver Transplantation

Shigenori EiABCDEF, Masahiro ShinodaABCDEF, Osamu ItanoB, Hideaki ObaraB, Minoru KitagoB, Taizo HibiABD, Hiroshi YagiB, Yuta AbeB, Kentaro MatsubaraB, Yoshihiro OnoAB, Shigeyuki KawachiB, Ken HoshinoB, Tatsuo KurodaAB, Minoru TanabeABCDEF, Yuko KitagawaAB

DOI: 10.12659/AOT.893421

Ann Transplant 2015; 20:357-365


BACKGROUND: Early initiation of enteral nutrition is recommended after some surgical procedures. This study retrospectively analyzed the effects of addition of early enteral nutrition (EEN) support during the postoperative phase in patients after living-donor liver transplantation (LDLT).

MATERIAL AND METHODS: The subjects were adult patients who underwent LDLT in our department and received either total parenteral nutrition (TPN) or EEN for postoperative nutritional support. We retrospectively compared clinical parameters between the TPN group (n=50) and the EEN group (n=45).

RESULTS: There were no significant differences in preoperative demographic data between the EEN and TPN groups with the exception of the follow-up period after surgery. In the EEN group, EEN was provided uneventfully; the daily amount of enteral nutrition was 996±465 kcal on postoperative day 7. Central venous catheters were removed significantly earlier in the EEN group than in the TPN group (postoperative day 11±7 vs. 28±18). The postoperative C-reactive protein level and the incidence of bacterial infection were significantly lower in the EEN group than in the TPN group. The postoperative length of hospital stay was significantly shorter and 6-month survival was significantly higher in the EEN group than in the TPN group. A multivariate analysis indicated that EEN was a significant factor for both shorter hospital stay and 6-month survival.

CONCLUSIONS: Our retrospective analyses suggest that introduction of EEN had a great impact on postoperative short-term outcomes of LDLT.

Keywords: Bacterial Infections and Mycoses, Enteral Nutrition, Length of Stay, Liver Transplantation, Survival

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358