10 December 2015 : Original article
Incidentally Small Pulmonary Nodule in Candidates for Living Donor Liver Transplantation
Yi-Ju WuABCDEF, Chih-Che LinACDEF, Yu-Hung LinBDEF, Shih-Ho WangAB, Ting-Lung LinAB, Chao-Long ChenAB, Allan M. ConcejeroAB, Yu-Ming ChangB, Hung-I LuAB, Chao-Chien WuBDDOI: 10.12659/AOT.895450
Ann Transplant 2015; 20:734-740
Abstract
BACKGROUND: The methods of differentiation and management of incidental small pulmonary nodules (ISN) in candidates for living donor liver transplantation (LDLT) are not well clarified. We aimed to share our experience and investigate the role of nodular size in application of ISN.
MATERIAL AND METHODS: From October 2009 to December 2012, 360 primary adult LDLTs were performed. Thirty-seven candidates with ISN and follow-up of over 2 years were collected. Subjects with pathologic reports of malignancy or infection composed group A, and those with pathologic reports of benign disease or stable lesions on CT image within 3~6 months composed group B.
RESULTS: Nodular size was significantly different between group A and B (7.68±3.77 mm versus 4.10±1.37 mm, respectively, p<0.001). Receiver-operating characteristic analysis showed area under the cure values (0.839 (95% confidence interval, 0.701~0.977); sensitivity, 81.3%; and specificity, 76.2%). Recurrent infection was not seen in 13 candidates with infectious ISN up to the median post-transplant follow-up of 40.70 months (range=24.4-61.7 months). Excluding 3 malignancy, 100% of the 34 candidates survived for over 2 years.
CONCLUSIONS: With 5 mm as the optimal cutoff, nodular size is a good predictor to differentiate malignant and infectious from benign ISN. For sizes less than 5 mm, follow-up of 3 months is recommended. For over 5 mm of ISN, it is recommended to obtain pathologic diagnosis and treat as diagnosis of infectious ISN.
Keywords: Liver Transplantation, Living Donors, solitary pulmonary nodule
SARS-CoV-2/COVID-19
17 June 2022 : Case report
Extrapulmonary Manifestations of SARS-CoV-2: A Report of 3 Cases and a Literature ReviewAnn Transplant In Press; DOI: 10.12659/AOT.935874
12 April 2022 : Letter/Correspondence
Pancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas Transpla...Ann Transplant 2022; 27:e935863
12 November 2021 : Original article
Coronavirus Disease 2019 (COVID-19) in Solid Organ Transplant Recipients: A Case-Control StudyAnn Transplant 2021; 26:e933152
26 October 2021 : Original article
Safety of Antithymocyte Globulin Use in Kidney Graft Recipients During the COVID-19 PandemicAnn Transplant 2021; 26:e933001
In Press
23 Jun 2022 : Original article
Evaluation of Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program in Comparison to S...Ann Transplant In Press; DOI: 10.12659/AOT.936514
21 Jun 2022 : Case report
Extrapulmonary Manifestations of SARS-CoV-2: A Report of 3 Cases and a Literature ReviewAnn Transplant In Press; DOI: 10.12659/AOT.935874
20 Jun 2022 : Original article
The Association Between Tacrolimus Levels and Hyperkalemia in Allograft Recipients Who Underwent Heart or L...Ann Transplant In Press; DOI: 10.12659/AOT.935607
15 Jun 2022 : Original article
Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant RecipientsAnn Transplant In Press; DOI: 10.12659/AOT.936276
Most Viewed Current Articles
26 Jan 2022 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
29 Dec 2021 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
24 Jul 2020 : Review article
Kidney Transplantation in the Times of COVID-19 – A Literature ReviewDOI :10.12659/AOT.925755
Ann Transplant 2020; 25:e925755
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860