Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

10 December 2015 : Original article  

Incidentally Small Pulmonary Nodule in Candidates for Living Donor Liver Transplantation

Yi-Ju WuABCDEF, Chih-Che LinACDEF, Yu-Hung LinBDEF, Shih-Ho WangAB, Ting-Lung LinAB, Chao-Long ChenAB, Allan M. ConcejeroAB, Yu-Ming ChangB, Hung-I LuAB, Chao-Chien WuBD

DOI: 10.12659/AOT.895450

Ann Transplant 2015; 20:734-740

Abstract

BACKGROUND: The methods of differentiation and management of incidental small pulmonary nodules (ISN) in candidates for living donor liver transplantation (LDLT) are not well clarified. We aimed to share our experience and investigate the role of nodular size in application of ISN.

MATERIAL AND METHODS: From October 2009 to December 2012, 360 primary adult LDLTs were performed. Thirty-seven candidates with ISN and follow-up of over 2 years were collected. Subjects with pathologic reports of malignancy or infection composed group A, and those with pathologic reports of benign disease or stable lesions on CT image within 3~6 months composed group B.

RESULTS: Nodular size was significantly different between group A and B (7.68±3.77 mm versus 4.10±1.37 mm, respectively, p<0.001). Receiver-operating characteristic analysis showed area under the cure values (0.839 (95% confidence interval, 0.701~0.977); sensitivity, 81.3%; and specificity, 76.2%). Recurrent infection was not seen in 13 candidates with infectious ISN up to the median post-transplant follow-up of 40.70 months (range=24.4-61.7 months). Excluding 3 malignancy, 100% of the 34 candidates survived for over 2 years.

CONCLUSIONS: With 5 mm as the optimal cutoff, nodular size is a good predictor to differentiate malignant and infectious from benign ISN. For sizes less than 5 mm, follow-up of 3 months is recommended. For over 5 mm of ISN, it is recommended to obtain pathologic diagnosis and treat as diagnosis of infectious ISN.

Keywords: Liver Transplantation, Living Donors, solitary pulmonary nodule

Add Comment 0 Comments

In Press

Original article  

Post-Liver Transplantation Atrial Fibrillation: Insights into Clinical and ECG Predictors

Ann Transplant In Press; DOI: 10.12659/AOT.948243  

Original article  

Prognostic Nutritional Index Trajectories Predict Kidney Function in Kidney Transplant Recipients: A Latent...

Ann Transplant In Press; DOI: 10.12659/AOT.947388  

Most Viewed Current Articles

03 Jan 2023 : Original article   6,942

Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...

DOI :10.12659/AOT.938467

Ann Transplant 2023; 28:e938467

15 Aug 2023 : Review article   6,909

Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ Transplantation

DOI :10.12659/AOT.939750

Ann Transplant 2023; 28:e939750

16 May 2023 : Original article   6,682

Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...

DOI :10.12659/AOT.939258

Ann Transplant 2023; 28:e939258

28 May 2024 : Original article   6,102

Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...

DOI :10.12659/AOT.943281

Ann Transplant 2024; 29:e943281

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358