Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

09 February 2016 : Clinical Research  

Predictors of Mortality in Abdominal Organ Transplant Recipients with Pseudomonas aeruginosa Infections

Honghui SuBCE, Qifa YeAF, Qiquan WanAC, Jiandang ZhouBDE

DOI: 10.12659/AOT.896269

Ann Transplant 2016; 21:86-93


BACKGROUND: Pseudomonas aeruginosa infection remains a common life-threatening complication after abdominal organ transplantation. The objective of the present study was to determine epidemiology and predictors of mortality in abdominal organ transplant recipients with P. aeruginosa infections.

MATERIAL AND METHODS: A retrospective, double-center study was performed over a 12-year study period. The epidemiology of P. aeruginosa infections was investigated and the univariate and multivariate analyses were performed to identify the independent risk factors for crude and infection-related 30-day mortality in abdominal organ transplant recipients with P. aeruginosa infections.

RESULTS: In this study, 60 episodes of P. aeruginosa infection occurring in 54 abdominal organ transplant recipients were enrolled. Postoperative P. aeruginosa infection occurred in 54 (2.8%) of 1935 abdominal organ transplant recipients. Most episodes of P. aeruginosa infections were nosocomial (75.9%, n=41). Among those 54 patients, 30 (55.6%) developed pulmonary infection and 13 (24.1%) developed bacteremia. In 25 of the 54 (46.3%) patients, P. aeruginosa isolates were multidrug resistant. There were 6 (11.1%) cases of septic shock, 18 (33.3%) infection-related deaths, and 21 (38.9%) crude 30-day deaths. Septic shock (odds ratio (OR)=13.46, 95% confidence interval (CI)=1.43–126.38, P=0.023) was identified as an independent risk factor for infection-related 30-day mortality. The risk factors independently associated with crude 30-day mortality included P. aeruginosa or concomitant bacteremia (OR=6.79, 95% CI=1.82–25.39, P=0.004) and a serum creatinine level of ≥1.5 mg/dL (OR=4.62, 95% CI=1.11–19.16, P=0.035).

CONCLUSIONS: The morbidity and mortality rates of P. aeruginosa infections were appreciable in abdominal organ transplant recipients. P. aeruginosa or concomitant bacteremia and an elevated serum creatinine level were associated with higher crude mortality, and septic shock independently predicted higher infection-related mortality.

Keywords: Bacterial Infections, Mortality, Organ Transplantation, Pseudomonas aeruginosa, Risk Factors

Add Comment 0 Comments

644 14

In Press

06 Jun 2023 : Original article  

A 15-Year Retrospective Study of Supportive Extracorporeal Therapies Including Plasma Exchange and Continuo...

Ann Transplant In Press; DOI: 10.12659/AOT.939745  

02 Jun 2023 : Original article  

Survival analysis of transplant-associated thrombotic microangiopathy under different diagnostic criteria a...

Ann Transplant In Press; DOI: 10.12659/AOT.939890  

10 May 2023 : Original article  

Incidence of Thromboembolic Complications Following Kidney Transplantation with Short and Extended Aspirin ...

Ann Transplant In Press; DOI: 10.12659/AOT.939143  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358