Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 April 2016 : Original article  

Pulmonary Cytomegalovirus Replication in Renal Transplant Patients with Late Onset Pneumonitis

Eva KönigshausenCDEF, Hartmut HengelD, Ortwin AdamsD, Heinz BryB, Stephan SteinerD, Christina PriegnitzDF, Anita HansenE, Lorenz SellinBC, Lars C. RumpE, Adina VoiculescuAEF

DOI: 10.12659/AOT.896938

Ann Transplant 2016; 21:235-240

Abstract

BACKGROUND: In renal transplant patients, pneumonitis may be caused by cytomegalovirus (CMV pneumonitis). This condition is usually accompanied by CMV viremia. However, CMV may also reactivate locally in the lungs of renal transplant patients with pneumonitis due to other pathogens. The impact of local CMV replication/reactivation in the lungs is unknown.

MATERIAL AND METHODS: All renal transplant patients at the Duesseldorf transplant center in the time from 01/2004 to 1/2008 were analyzed concerning pulmonary CMV replication in the setting of pneumonitis.

RESULTS: Of 434 renal transplant recipients, 25 patients were diagnosed with pneumonitis. From these 25 patients with pneumonitis, 7 presented with isolated pulmonary CMV replication but without relevant CMV viremia 8±4.2 months after renal transplantation. Three of the 7 patients needed long-term respiratory support by invasive mechanical ventilation. Pulmonary opportunistic infections were diagnosed in 6 of the 7 patients. Therapy consisted of a reduction in immunosuppression, ganciclovir, and antibiotics.

CONCLUSIONS: Our findings suggest that pulmonary CMV replication occurs in renal transplant patients with pneumonitis even at later phases after renal transplantation. This finding seems to be a frequent complication (7/25 patients). Clinicians should be aware of this condition because blood-based screening assays for CMV will remain negative.

Keywords: Kidney Transplantation, Lung Diseases, Interstitial

Add Comment 0 Comments

In Press

Original article  

Urinary Chemokines CXCL9 and CXCL10 Are Non-Invasive Biomarkers of Kidney Transplant Rejection

Ann Transplant In Press; DOI: 10.12659/AOT.944762  

Original article  

Risk Factors for Graft Failure After Penetrating Keratoplasty in Eastern China from 2018 to 2021

Ann Transplant In Press; DOI: 10.12659/AOT.945388  

Original article  

Predictive Model for Post-Transplant Renal Fibrosis Using Ultrasound Shear Wave Elastography

Ann Transplant In Press; DOI: 10.12659/AOT.945699  

Original article  

The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival Afte...

Ann Transplant In Press; DOI: 10.12659/AOT.945249  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,977

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

22 Nov 2022 : Original article   10,134

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

12 Jan 2022 : Original article   9,446

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

15 Mar 2022 : Case report   7,198

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358