20 September 2016 : Original article
Effect of Fibrin Glue on the Incidence of Surgical Complications After Living-Related-Donor Kidney Transplantation: Results of a Randomized Clinical Trial
Clotilde Fuentes-OrozcoABCDEFG, Salvador González-MercadoABCDEF, Joel Mario Sandoval-SandovalBCE, Carlos Valdespino-MejíaBCE, Eduardo González-GonzálezBCE, Juan Narciso Ramírez-RoblesBCE, Benjamín Gómez-NavarroBCE, Blanca Estela Dávalos-DelgadilloABCD, Leticia Marquez-LeañoABCD, Mariana Chávez-TostadoBCDEF, Anais Ramírez-ArceBCDEF, Elizabeth Andalón-DueñasBCDEF, Arturo Espinosa-PartidaBCDEF, Michel Dassaejv Macías-AmezcuaBCDEF, Alejandro González-OjedaABCDEFGDOI: 10.12659/AOT.899821
Ann Transplant 2016; 21:587-595
Abstract
BACKGROUND: The incidence of surgical complications after kidney transplantation ranges from 10–25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation.
MATERIAL AND METHODS: A controlled clinical trial involving 78 recipients randomly assigned to receive fibrin glue and 79 in the control group without the application of fibrin glue. Patients were followed for six months after surgery.
RESULTS: The average ages were 24.8±9.4 and 27.4±11.3 years in the control and study groups, respectively (p=0.11). Individual morbidities, such as urologic, lymphatic, vascular, and wound complications, were not statistically different between groups; however, the total number of surgical complications observed were in five patients in the study group and 16 patients in the control group. This difference was statistically significant (p<0.01, relative risk 0.44, 95% CI 0.20–0.97). There was no mortality or adverse reaction to fibrin glue. One kidney graft was lost because of uncontrollable bleeding secondary to tearing of the renal capsule. The incidence of early medical complications was similar between groups.
CONCLUSIONS: Applications of the biological adhesive reduced the incidence of surgical complications.
Keywords: Fibrin Tissue Adhesive, Kidney Transplantation, Morbidity
In Press
Original article
Biopsychosocial Effects of Donor Traits on Heart Transplant RecipientsAnn Transplant In Press; DOI:
Clinical Research
Ten-Year Retrospective Analysis of Continuous Renal Replacement Therapy in Burn Patients: Impact on Surviva...Ann Transplant In Press; DOI:
Original article
Factors Influencing Stress Disorders in Intensive Care Unit (ICU) Patients After Liver Transplantation: A C...Ann Transplant In Press; DOI: 10.12659/AOT.944320
Original article
Hepatopulmonary Syndrome and Liver Transplantation: Impact on Survival and Postoperative ComplicationsAnn Transplant In Press; DOI: 10.12659/AOT.945297
Most Viewed Current Articles
05 Apr 2022 : Original article 13,123
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
22 Nov 2022 : Original article 10,365
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
12 Jan 2022 : Original article 9,634
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
15 Mar 2022 : Case report 7,286
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860