06 December 2016 : Original article
De Novo Renal Neoplasia After Kidney Transplantation According to New 2016 WHO Classification of Renal Tumors
Albino Eccher1ABDEF, Luigino Boschiero2ABEF, Brett Delahunt3DE, Luca Cima1CEF, Francesca Fior2B, Francesco Nacchia2B, Momo Rostand2B, Amedeo Carraro4B, Umberto Tedeschi4B, Gianluigi Zaza5B, Marilena Casartelli Liviero6BE, Laura Zampicinini6BE, Marco Chilosi1AE, Giuseppe Feltrin7ABE, Claudio Rago7ABE, Antonietta D'Errico8EF, Claudio Ghimenton1CDF, Guido Martignoni19ADEG, Matteo Brunelli110ABDEFG*DOI: 10.12659/AOT.900386
Ann Transplant 2016; 21:745-754
Abstract
BACKGROUND: De novo renal neoplasia developing after kidney transplantation at Verona Kidney Transplant Center were reviewed according to new 2016 WHO Renal Tumor Classification.
MATERIAL AND METHODS: Primary renal tumors developed in native or transplanted kidneys de novo following renal transplantation were retrieved and histologically reviewed by three expert uropathologists. Immunoexpression of the diagnostic antigens CD13, CD10, CK7, CK34bE12, AMACR, CAIX, AE1/AE3, CK14, GATA-3, HMB-45, cathepsin-k, S100A1, and parvalbumin was assessed. Predictive antigens ph-mTOR and ph-p70S6k were also tested.
RESULTS: Two thousands and sixteen kidney transplantations have been carried out from 1968–2015. Follow-up was available per 1,646 patients (mean 8.4 years). We observed 16 cases of de novo renal neoplasia arising in patients 16 to 286 months post-transplantation. Nine clear cell, two papillary RCCs and a single case of the new WHO entity denominated “acquired cystic disease-associated RCC” were identified in native kidneys. Another new WHO tumor entity called “clear cell papillary RCC” was diagnosed and a new variant of papillary RCC with diffuse clear cytoplasm was also identified. The majority of tumors were low stage and low grade according to the new ISUP grading system. Seven patients were additionally treated with mTOR inhibitors. Post-cancer follow-up ranged from 62 to 281 months. One patient showed a recurrence (a lung metastases) and died. Of the remaining patients, three died of non-cancer-related causes.
CONCLUSIONS: The application of the new WHO 2016 classification has importance as it identifies new (18% of tumors) morphotypes that are likely to behave in a less aggressive fashion.
Keywords: Carcinoma, Renal Cell, Kidney Neoplasms, Kidney Transplantation, World Health Organization
1165 16
In Press
10 Nov 2023 : Original article
Effects of Preservation of Donor Liver Gastroduodenal Artery on Post-Transplant Biliary Complications in 18...Ann Transplant In Press; DOI: 10.12659/AOT.941699
07 Nov 2023 : Original article
Allogeneic Hematopoietic Stem Cell Transplantation Can Improve Prognosis of Extramedullary Infiltration Pos...Ann Transplant In Press; DOI: 10.12659/AOT.942197
06 Nov 2023 : Original article
Clinical Outcomes of Administration of Rituximab for Desensitization in Liver Transplant Patients with Pref...Ann Transplant In Press; DOI: 10.12659/AOT.941456
06 Nov 2023 : Original article
Short-Term Monitoring of Graft Regeneration in Partial Liver Transplantation RecipientsAnn Transplant In Press; DOI: 10.12659/AOT.941444
Most Viewed Current Articles
24 Aug 2021 : Review article
Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future PerspectivesDOI :10.12659/AOT.931664
Ann Transplant 2021; 26:e931664
26 Jan 2022 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
29 Dec 2021 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860