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18 November 2016 : Original article  

Does Matching Donor-Recipient Age Affect Long-Term Survival in Liver Transplantation?

Cristina DopazoABCDEF, Itxarone BilbaoADE, Lluis CastellsADF, Mireia CaraltEF, Elena Fernández de SevillaBEF, José Luis LázaroE, Ramón CharcoADEF

DOI: 10.12659/AOT.900767

Ann Transplant 2016; 21:708-716

Abstract

BACKGROUND: The characteristics of liver donors have changed over the last decade owing to the shortage of organs and high mortality on the waiting list, leading to wider use of extended-criteria donors, including older donors. The aim of this study was to evaluate the effect of matching donor-recipient age on morbidity at 1 year post-transplant and on long-term patient and graft survival.

MATERIAL AND METHODS: Retrospective study from a prospectively-obtained database including adult patients who had received a primary liver transplant (LT) from whole graft of brain-dead donors. Recipients were divided into 2 age groups: <60 years and ≥60 years. Both groups were sub-divided according to donor age (younger than 60 years and 60 years or older). A propensity score analysis was performed to further adjust for baseline differences between recipients and donors.

RESULTS: We analyzed 642 patients who had LT performed between January 2000 and December 2013. No differences were observed in 1-year morbidity (hospital stay, rejection, surgical complications, and retransplant) between groups. Although patient and graft survival was significantly impaired in the older donor/older recipient group on Kaplan-Meier analysis (p=0.004), the propensity score analysis showed that donor age ≥60 years did not increase the risk of death for recipients aged ≥60 (HR1.40, p 0.074) and <60 years (HR 1.47, p 0.070).

CONCLUSIONS: Older donor age did not negatively affect survival regardless of recipient age, and comparable outcomes were achieved without an increased rate of complications.

Keywords: Liver Transplantation, Morbidity, Mortality

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358