11 April 2017 : Original article
Application of Indocyanine Green (ICG) Detection in Evaluating Early Prognosis in Patients with Fatty Liver Disease After Liver Transplantation
Wenjing Wang1ABDEF, Qiang Zhao1CF, Anbin Hu1EF, Xiaoshun He1A, Xiaofeng Zhu1AE*DOI: 10.12659/AOT.901277
Ann Transplant 2017; 22:208-214
Abstract
BACKGROUND: The relationship between the clearance rate of ICG (indocyanine green) and varying degrees of liver fatty degeneration remains to be explored. The value of ICG detection in the evaluation of early prognosis following hepatic transplantation has been rarely investigated.
MATERIAL AND METHODS: Clinical data of 106 patients undergoing liver transplantation were retrospectively analyzed. The severity of fatty degeneration of the resected liver specimens was assessed by pathological biopsy. All patients were assigned into one of three groups: A (no fatty degeneration), B (<20% hepatic fatty degeneration) or C (20–40% hepatic fatty degeneration). Multiple parameters were statistically compared among the three groups before, during, and after liver transplantation.
RESULTS: The results demonstrated that R15-D (15 minute detection rate of ICG in the donors) was positively correlated with R15-R (15 minute detection rate of ICG in the recipients). After liver transplantation, the peak values of ALT and total bilirubin (TB), and the R15-R and the rate of early allograft dysfunction (EAD) in group C were the highest among all three groups. However, the 3-month and 6-month survival rate of the grafts and the 1-year survival rate of the patients in group A were considerably lower compared to groups B and C. The area under the curve (AUC) of R15-R in predicting the EAD, 3-month survival rate and 6-month survival rate of the grafts and the 1-year survival rate of the patients was 0.956, 0.827, 0.867, and 0.794, respectively.
CONCLUSIONS: ICG detection rate can be used to predict the early prognosis of patients diagnosed with moderate liver fatty degeneration.
Keywords: Lipid Peroxides, Liver Transplantation
In Press
Original article
Simultaneous Liver and Kidney Transplant in a Middle-Income Country: A Single-Center ExperienceAnn Transplant In Press; DOI: 10.12659/AOT.947649
Original article
Outcomes of Combined Liver-Kidney Transplantation in Polycystic Liver and Kidney DiseaseAnn Transplant In Press; DOI: 10.12659/AOT.947639
Most Viewed Current Articles
03 Jan 2023 : Original article 6,872
Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...DOI :10.12659/AOT.938467
Ann Transplant 2023; 28:e938467
15 Aug 2023 : Review article 6,817
Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ TransplantationDOI :10.12659/AOT.939750
Ann Transplant 2023; 28:e939750
16 May 2023 : Original article 6,561
Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...DOI :10.12659/AOT.939258
Ann Transplant 2023; 28:e939258
28 May 2024 : Original article 5,900
Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...DOI :10.12659/AOT.943281
Ann Transplant 2024; 29:e943281