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18 April 2017 : Original article  

Intervention Therapy for Portal Vein Stenosis/Occlusion After Pediatric Liver Transplantation

Haijun Gao1BCE, Hao Wang1ACD, Guang Chen1ABE*, Zhengjia Yi1ADE

DOI: 10.12659/AOT.902239

Ann Transplant 2017; 22:222-229

Abstract

BACKGROUND: The aim of this study was to investigate the outcomes and stent implantation timing of portal vein stenosis intervention after pediatric liver transplantation (pLT).

MATERIAL AND METHODS: The clinical data of 30 children with post-liver transplantation portal vein stenosis/occlusion (PVS/O) between Jan 2008 and Jun 2015 were retrospectively analyzed. The successfully re-opened cases used balloon angioplasty or stent implantation. SPSS13.0 software was used for statistical analysis and paired t test of the pressure gradient at both ends of the stenosis, diameter and flow rate within the stenosis, platelet count, and albumin in the PVS children before and after balloon angioplasty, with p<0.05 considered as statistically significant. Among the 30 patients, 6 received a stent implant in their first treatment, 22 received balloon angioplasty in their first treatment, and in 2 the re-opening could not be achieved.

RESULTS: The diameter of the stenotic segment, portal vein velocity, pressure gradient at both ends of the stenosis, and platelet count in these children with portal vein stenosis/occlusion (PVS/O) showed statistically significant differences when comparing values before and after intervention (p<0.05), but albumin showed no statistically significant difference (p>0.05).

CONCLUSIONS: Intervention therapy for portal vein stenosis after pediatric liver transplantation (pLT-PVS) is a safe and effective treatment, and patients with portal vein torsion, intimal tearing, or long portal vein segment occlusion should undergo stent implantation.

Keywords: Hospitals, Pediatric, Intervention Studies, Portal Vein

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358