18 August 2017 : Original article
A New Score to Predict Recipient Mortality from Preoperative Donor and Recipient Characteristics in Living Donor Liver Transplantation (DORMAT Score)
Raghavendra Babu1ABCDF, Pulkit Sethi1BCDEF*, Sudhindran Surendran1AEF, Puneet Dhar1F, Unnikrishnan Gopalakrishnan1F, Dinesh Balakrishnan1F, Ramachandran Narayana Menon1F, Binoj Sivasankarapillai Thankamonyamma1F, Sudheer Othiyil Vayoth1F, Manoj Thillai1FDOI: 10.12659/AOT.904350
Ann Transplant 2017; 22:499-506
Abstract
BACKGROUND: Recipient outcomes in adult living donor liver transplantation depend on various characteristics in both recipient and donor. We aimed to derive a score based upon preoperative characteristics in donor and recipient that could predict the recipient mortality in adult living donor liver transplantation.
MATERIAL AND METHODS: Retrospective data of 100 living donor liver transplantation recipients and their respective donors were analyzed for preoperative factors that correlated with recipient mortality. Statistically significant factors were weighted appropriately to derive a regression equation to obtain a donor-to-recipient match (DORMAT) score. This score was applied to 71 patients prospectively and their outcome was analyzed.
RESULTS: Donor-recipient match (DORMAT) score, derived using regression analysis of the significant variables was [0.002 (Recipient age) + 0.013 (Recipient BMI) + 0.055 (SBP) + 0.344 (HRS) + 0.022 (Pre-op culture positivity) + 0.01 (Donor age) – 0.639]×100. DORMAT score, when validated to a prospective cohort of 71 adult-to-adult LDLT patients, had a C-statistic (area under ROC curve) of 0.712. The mortality rate was seen to increase with increasing DORMAT score.
CONCLUSIONS: DORMAT score is a useful clinical decision-making tool to predict recipient mortality in adult living donor liver transplantation.
Keywords: Fatty Liver, hepatorenal syndrome, Liver Cirrhosis, Transplants
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