Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

17 November 2017 : Original article  

Heart Transplantation and Risk of Cardiac Vasculopathy Development: What Factors Are Important?

Małgorzata Sobieszczańska-Małek1ABCDEF*, Jerzy Korewicki1ADF, Krzysztof Komuda1BDF, Małgorzata Karczmarz1BDF, Sylwia Szymańska2BDE, Alicja Cicha-Mikołajczyk3CD, Paweł Bekta4BD, Adam Parulski5BD, Maciej Pronicki2BD, Wiesława Grajkowska6BD, Grzegorz Małek7BCE, Przemysław Leszek8CE, Maria Kaczorowska9BF, Mariusz Kuśmierczyk5AD, Tomasz Zieliński8ACDEG

DOI: 10.12659/AOT.905267

Ann Transplant 2017; 22:682-688

Abstract

BACKGROUND: The aim of this study was to find the main risk factors for development of cardiac allograft vasculopathy (CAV), especially factors identified before the surgical procedure and factors related to the recipient profile and the medical history of the donor.

MATERIAL AND METHODS: There were 147 patients who had heart transplantation (HT) included in this study: mean age was 45.8±15.3 years. All study patients had coronary angiography after HT. Analyzed risk factors were: non-immunologic recipient risk factors (age of transplantation, smoking, hypertension, lipids, diabetes, obesity and weight gain after HT), immunologic recipient risk factors (acute cellular rejection (ACR), acute humoral rejection (AMR), cytomegalovirus (CMV) episodes), and donor-related risk factors (age, sex, catecholamine usage, ischemic time, compatibility of sex and blood groups, cause of death, cardiac arrest).

RESULTS: CAV was recognized in 48 patients (CAV group); mean age 53.6±13.6 years. There were 99 patients without CAV (nonCAV group); mean age 48.3±15.5 years. A univariate Cox analysis of the development of coronary disease showed statistical significance (p<0.05) for baseline high-density lipid (HDL), ACR, AMR, CMV, and donor age. Multivariate Cox regression model confirmed that only baseline HDL, episodes of ACR, donor age, and CMV infection are significant for the frequency of CAV after HT.

CONCLUSIONS: Older donor age is highly associated with CAV development. Older donor age and low level of HDL in heart recipients with the strongest influence of immunologic risk factors (ACR, CMV infection) were linked with development of CAV.

Keywords: Coronary Artery Disease, Heart Transplantation, Risk Factors

Add Comment 0 Comments

In Press

Original article  

Simultaneous Liver and Kidney Transplant in a Middle-Income Country: A Single-Center Experience

Ann Transplant In Press; DOI: 10.12659/AOT.947649  

Original article  

Outcomes of Combined Liver-Kidney Transplantation in Polycystic Liver and Kidney Disease

Ann Transplant In Press; DOI: 10.12659/AOT.947639  

Most Viewed Current Articles

03 Jan 2023 : Original article   6,881

Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...

DOI :10.12659/AOT.938467

Ann Transplant 2023; 28:e938467

15 Aug 2023 : Review article   6,826

Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ Transplantation

DOI :10.12659/AOT.939750

Ann Transplant 2023; 28:e939750

16 May 2023 : Original article   6,569

Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...

DOI :10.12659/AOT.939258

Ann Transplant 2023; 28:e939258

28 May 2024 : Original article   5,905

Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...

DOI :10.12659/AOT.943281

Ann Transplant 2024; 29:e943281

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358