Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

23 March 2018 : Original article  

Normothermic Machine Perfusion versus Cold Storage of Liver in Pig Model: A Meta-Analysis

Shiqi Bian1ABCDEF, Zhijun Zhu123ABCDEFG*, Liying Sun123ADEF, Lin Wei12DF, Wei Qu12DF, Zhigui Zeng12DF, Ying Liu12DF

DOI: 10.12659/AOT.908774

Ann Transplant 2018; 23:197-206

Abstract

BACKGROUND: Normothermic machine perfusion (NMP) is a novel strategy used for organ preservation. We aimed to determine the overall efficacy of NMP for liver preservation versus traditional static cold storage (CS).

MATERIAL AND METHODS: We performed a meta-analysis of the literature to evaluate the efficacy of NMP in experimental pig models of liver preservation. We use the standardized mean difference and 95% confidence intervals (CI) to calculate statistics and used the random effects model for the combined analysis of the results.

RESULTS: A total of 16 studies from 12 published articles were included. The combined results showed that NMP significantly decreased alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hyaluronic acid levels in serum or perfusate, significantly increased bile production, and had a similar 5–7-days survival rate after liver transplantation compared with the CS group.

CONCLUSIONS: NMP provides superior graft preservation compared with CS in the pig model.

Keywords: Equipment and Supplies, Liver Transplantation, meta-analysis, Organ Preservation, Perfusion, Reperfusion Injury

Add Comment 0 Comments

929 9

In Press

17 May 2023 : Original article  

Results of Liver Retransplantation After Rescue Hepatectomy: A Single-Center Study

Ann Transplant In Press; DOI: 10.12659/AOT.939557  

10 May 2023 : Case report  

Outcomes from a Single Transplant Center of 5 Pediatric Cases of Domino Liver Transplantation from Live Don...

Ann Transplant In Press; DOI: 10.12659/AOT.939893  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358