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23 March 2018 : Original article  

Normothermic Machine Perfusion versus Cold Storage of Liver in Pig Model: A Meta-Analysis

Shiqi Bian1ABCDEF, Zhijun Zhu123ABCDEFG*, Liying Sun123ADEF, Lin Wei12DF, Wei Qu12DF, Zhigui Zeng12DF, Ying Liu12DF

DOI: 10.12659/AOT.908774

Ann Transplant 2018; 23:197-206

Abstract

BACKGROUND: Normothermic machine perfusion (NMP) is a novel strategy used for organ preservation. We aimed to determine the overall efficacy of NMP for liver preservation versus traditional static cold storage (CS).

MATERIAL AND METHODS: We performed a meta-analysis of the literature to evaluate the efficacy of NMP in experimental pig models of liver preservation. We use the standardized mean difference and 95% confidence intervals (CI) to calculate statistics and used the random effects model for the combined analysis of the results.

RESULTS: A total of 16 studies from 12 published articles were included. The combined results showed that NMP significantly decreased alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hyaluronic acid levels in serum or perfusate, significantly increased bile production, and had a similar 5–7-days survival rate after liver transplantation compared with the CS group.

CONCLUSIONS: NMP provides superior graft preservation compared with CS in the pig model.

Keywords: Equipment and Supplies, Liver Transplantation, meta-analysis, Organ Preservation, Perfusion, Reperfusion Injury

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358