08 March 2023 : Original article
[In Press] Evaluation and Use of Organs from Donors Poisoned by Organophosphorus PesticideJi-hua Wu1AF, Xi-hua Ma1BCD, Jian-hui Dong1EF, Ning Wen1CD, Ke Qin1BCD, Liu-gen Lan1EF, Ji-xiang Liao1B, Zhi-ying Lei2CDF, Hai-bin Li1AE, Xu-yong Sun1AFG
Ann Transplant In Press; DOI: 10.12659/AOT.939343
Available online: 2023-03-08, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
The aim of this study was to explore the evaluation and use of donor organs from donors with brain death caused by acute severe organophosphorus pesticides and provide a basis for the use of such donor organs.
MATERIAL AND METHODS
Seven cases of brain dead donors caused by acute organophosphorus pesticide poisoning from January 2014 to December 2018 in the hospital were collected, and a retrospective analysis was made of the donors’ age, race, physiological and pathological changes, donor organ function changes and the organ use, liver or kidney function recovery, and complications of the recipients. The 18 recipients were followed up until June 31, 2022.
We found that 71.42% of organ donors were male, and 71.42% of organ donors were under 50 years old. The main cause of death was respiratory failure caused by organophosphorus pesticide poisoning. The liver and kidney functions of 7 donors were damaged, and 3 livers could not be used due to severe functional damage, but the liver or kidney function of 18 recipients gradually recovered after transplantation. Delayed recovery of graft function occurred after transplantation accounted for 21.43%, and the grafts had good short-term to medium-term performance.
Although the function of organs from donor with brain death due to acute severe organophosphorus pesticide poisoning is seriously damaged, most of the organs can still be used for transplantation. Individualized functional maintenance according to the situation of donors is conducive to improving the quality of organs.
Keywords: Brain Death; Organ Transplantation; Organophosphate Poisoning; Tissue and Organ Procurement
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