21 May 2009
Dyslipidaemia in lung transplant recipients during short and long term follow UP
S Zeglen, J Wojarski, E Wozniak-Grygiel, R Buldak, E Kucewicz, M ZembalaAnn Transplant 2009; 14(1): 61-61 :: ID: 880421
Abstract
Background: Hypercholesterolemia is a frequent complication in lung transplant recipients but the mechanisms contributing to its development are not exactly known.
Material/Methods: Total cholesterol levels (Chol, [mmol/L]) as well as lipoproteins like HDL (mmol/L), LDL (mmol/L) and TG, (mmol/L) were retrospectively analysed in 15 lung transplant recipients (2 women and 13 men, mean age 46.2±12.1, BMI 20.5±4.2) in various post-transplantation periods (early-eTP up to 30 days and long-lTP up to two years after LTx). Lipoproteins were estimated using routine enzyme/colorimetric method (Cobas-Integra).
Results: In eTP period mean cholesterol value was 4.57±0.37 (in 23% of patients values were above normal); HDL was 1.03±0.19 (in 30.8% values were decreased); mean LDL value was 2.8±0.36 (30.8% values above the normal); TG 2.26±0.66 were upregulated (in 61.5% patients upper than normal). Mean cholesterol in late period (lTP) was 4.01±0.53 (in 16.7% patients above normal); HDL 1.25±0.23 (in 8.3% of subjects values were down-regulated); LDL was 2.49±0.54 (16.7% of patients presented increased values); TG were 1.55±0.43 (33.3% of patients had upper values than normal). There were no differences in lipid disturbances between studied periods. There was no difference in lipids between tacrolimus and cyclosporine groups with an exception of total cholesterol (4.09±0.4 vs. 4.92±0.97 p<0.05; HDL 1.14±0.26 vs. 1.23±0.21 p>0.05; LDL 2.36±0.45 vs. 3.07±0.73 p>0.05; TG 1.48±0.47 vs. 2.25±0.57).
Conclusions: Clinically significant percentage of patients presented atherogenic constellation of lipoproteins -high TG, LDL and low HDL. It could also be
concluded that tacrolimus might be less atherogenic than cyclosporine.
Keywords: Lung Transplantation
In Press
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
02 Apr 2024 : Original article
Liver Transplantation from Brain-Dead Donors with Hepatitis B or C in South Korea: A 2014-2020 Korean Organ...Ann Transplant In Press; DOI: 10.12659/AOT.943588
02 Apr 2024 : Original article
Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...Ann Transplant In Press; DOI: 10.12659/AOT.943281
03 Apr 2024 : Review article
Alternative Therapies in Transplantology as a Promising Perspective in MedicineAnn Transplant In Press; DOI: 10.12659/AOT.943387
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860