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03 October 2023: Original Paper  

Impact of Blood Pressure on Risk of Graft Failure or Death Among Patients After Kidney Transplantation in a 10-Year Observational Period: A Single-Center Retrospective Analysis

Tomasz Pilecki1ABCDEF, Bożena Czarkowska-Pączek ORCID logo2ACDEF*, Wojciech Lisik ORCID logo3BCD, Sławomir Nazarewski ORCID logo4BCD, Leszek Pączek ORCID logo1ABCDEF

DOI: 10.12659/AOT.939472

Ann Transplant 2023; 28:e939472



BACKGROUND: Hypertension is a risk factor for graft failure and mortality among kidney transplant recipients (KTRs). The aim of the study was to examine blood pressure (BP) as a factor that contributes to graft failure or death during a 10-year observation period.

MATERIAL AND METHODS: The study group comprised 70 KTRs who were treated according to their clinical state. Data were collected at 1 month and 1 year after transplantation and included office and ambulatory BP monitoring (ABPM) BP values, eGFR, proteinuria, and BMI. During the observation period, 6 patients died, and 10 lost the graft, but not during the first year.

RESULTS: Office and ABPM BP values were within normal ranges and did not differ from each other. eGRF and BMI were higher at 1 year compared to 1 month after transplantation, and proteinuria decreased. Among those who died, DBP was lower compared to those of survivors with graft failure. Proteinuria and donor age were positively correlated with BP.

CONCLUSIONS: Monitoring of BP and adequate treatment of hypertension resulting in BP values within normal values among KTRs contribute to longer survival of the graft and recipient. Older donor age and proteinuria could predict post-transplant hypertension. Low diastolic BP of the recipient could increase the risk of death among KTRs. Despite the fact that ABPM is the blood pressure measurement method of choice, appropriate standard office measurement could also be used for BP monitoring.

Keywords: Kidney Transplantation, Hypertension, Graft Rejection, Humans, Blood Pressure, Retrospective Studies, Blood Pressure Monitoring, Ambulatory, Proteinuria


Transplantation is currently the treatment of choice for patients with end-stage renal disease (ESRD) and is associated with reduced mortality due to many factors, including cardiovascular disease (CVD). However, the population of kidney transplant recipients (KTRs) still remains at higher risk for CVD compared to the general population [1–3]. Hypertension is one of the most common traditional risk factors for CVD in this population, with prevalence between 70% and 95% [2,4–7].

The differences in the epidemiological data regarding hypertension in KTRs derive from different cut-off values. According to the Kidney Disease Improving Global Outcomes Guidelines (KDIGO) issued in 2021, hypertension is diagnosed when office blood pressure (BP) is higher than 130/80 mmHg and ambulatory BP monitoring (ABPM) exceeds 125/75 mmHg [2,8]. These values are in line with those proposed by the American College of Cardiology/American Heart Association in 2017 [9], but they differ from those established by the European Society of Cardiology/European Society of Hypertension in 2018, in which the cut-off values were 140/90 mmHg and 130/80 mmHg for office measurement and ABPM, respectively [2,10].

Risk factors for post-transplant hypertension include recipient factors present before transplantation, such as longstanding hypertension, genetic profile, age, increased body mass index (BMI), and endocrine factors. They also include factors related to ESKD and the transplantation itself, such as the donor’s pre-transplantation hypertension, donor age, higher than recommended sodium intake, poor allograft quality, the specific donor’s genetic profile or acute or chronic allograft rejection, and immunosuppressive medications, particularly steroids [11–13]. Literature data indicate that lowering systolic BP (SBP) decreases the risk of CVD and the overall mortality among KTRs. Is has also been attributed to better kidney function and graft survival. But despite these facts, the optimal BP among KTRs is still uncertain [2,14].

The main goal of post-transplant care is to improve graft and patient survival. Hypertension is established as a risk factor that could interfere with this goal. Therefore, we aimed to evaluate blood pressure monitoring and the possible impact on graft failure (GF) or patient death during a 10-year follow-up period.

Material and Methods


Statistical analyses were performed using IBM SPSS Statistics 25.0. Descriptive statistics were generated using standard parameters, including percentage, mean, and standard deviation. Between-group differences were analysed using a t test for dependent groups, and for multiple measures, repeated-measures analysis of variance was used. For comparison between the 2 groups of quantitative variables, the Mann-Whitney U test was used. Fisher’s exact test was used for categorical variables.

To detect significant relationships between variables, Pearson’s methods were applied for quantitative variables. For categorical variables and quantitative variables, predictive solution Eta was applied. Cox proportional-hazards regression analysis was used to estimate the impact on GF (death or graft lost) of SBP, DBP, and the coefficient of variation (CV) of BP. Results were considered significant at P<0.05.


The selected clinical parameters, eGFR, proteinuria, and BMI evaluated at 1mTx and 1yTx are shown in Table 1. eGRF and BMI significantly increased at 1yTx compared to 1mTx, and proteinuria significantly decreased.

Table 2 shows the results of SO, ABPM SBP and DBP (mean values from a 24-h period), and a comparison between these measures. All values were within normal ranges, but SBP was significantly lower at 1yTx compared to 1mTx (SO: 130.76±12.39 vs 134.67±15.05, P =0.047; ABPM: 129.67±10.67 vs 136.89±16.54, P<0.001). There were no significant differences in DBP. There were also no statistically differences between SBP and DBP measured by SO compared to mean values measured by ABPM.

Table 3 shows the mean values of ABPM SBP and DBP during the daytime (D, 6 am to 10 pm) and night (N, 10 pm to 6 am the next day) at 1mTx and 1yTx and a comparison between these measures. 1mTx SBP was higher at night compared to the day, whereas DBP did not differ. At 1yTx, both SBP and DBP were higher during the day compared to night.

We assessed the correlations between mean values of SBP and DBP measured by ABPM at 1mTx and 1yTx, recipient and donor age, recipient and donor sex, recipient eGFR, proteinuria, and BMI. A positive correlation was found between SBP at 1mTx and donor age (r=0.33, P=0.006), and SBP at 1yTx was positively correlated with donor age (r=0.25, P=0.034) and proteinuria (r=0.32, P=0.007). There were no correlations between other pairs of variables.

To investigate the impact of hypertension on both GF (graft failure or recipient death [RD]) and RD alone, we observed the recipients for 10 years. During this period, 6 recipients died (but not during the first year of observation), while 10 patients experienced graft lost and were referred to dialysis. The comparison between GF and survivors did not show any differences at 1mTx or 1yTx in mean values of SBP and DBP measured by ABPM, day and night ABPM SBP and DBP. The results are shown in Table 4.

To show the potential impact of BP values on the risk of death among GF group, we compared those who lost the graft (GL) with the group of patients who died (RD). This revealed a significantly lower mean value of DBP measured by ABPM and values during day and night at 1mTx, but not after 1yTx in the RD group. The results are shown in Table 5.

We investigated the impact of mean values of SBP and DBP measured with ABPM and the CV of SBP and DBP (standard deviation/mean value) at 1mTx and 1yTx on the GF using Cox regression analysis. SBP and DBP and the CV of SBP and DBP did not influence GF.



KTRs are a special group of patients with multiple diseases, who undergo complex therapy, and several factors that are different from the general population could influence the hypertension outcomes. The number of patients included into the study was limited, which could have biased the results.


In conclusion, close monitoring of BP and adequate treatment of possible hypertension resulting in BP values within normal and advised ranges among KTRs contribute to longer graft and recipient survival. Older donor age and proteinuria could predict post-transplant hypertension. Low diastolic BP of the recipient could increase the risk of death among KTRs. Despite the fact that ABPM is the BP measurement method of choice, appropriate standard office measurement could also be used for BP monitoring.


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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358